Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Charles P. Fulco, Joseph Nasser, Thouis R. Jones, +16

Nature Genetics

Transcriptional RegulationNatural SciencesMolecular BiologyGene EditingGenome Editing +6

Genome-wide enhancer maps link risk variants to disease genes

Joseph Nasser, Drew T. Bergman, Charles P. Fulco, +29

Nature

Genome-wide Association StudyGeneticsRisk VariantsComplex DiseaseGenomics +1

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Alexander G. Bick, Joshua S. Weinstock, Satish K. Nandakumar, +405

Nature

Genetic DisorderGeneticsHematologyInherited CausesChromosomal Rearrangement +1

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

E. Weeks, Jacob C. Ulirsch, Nathan Cheng, +24

Nature Genetics

Genome-wide Association StudyGenetic AnalysisFunctional GenomicsGenotype-phenotype AssociationGene Recognition +12

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, +10

Nature Genetics

Genome-wide Association StudyMedicineGeneticsGenetic EpidemiologyPathology +11

Compatibility rules of human enhancer and promoter sequences

Drew T. Bergman, Thouis R. Jones, Vincent Liu, +12

Nature

Transcriptional RegulationCompatibility RulesGeneticsGene ExpressionMedicine +1

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

E. Weeks, Jacob C. Ulirsch, Nathan Cheng, +24

GeneticsPolygenic RiskGenetic EpidemiologyGenomicsGene Recognition +19

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, +38

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Yakir Reshef, Hilary K. Finucane, David R. Kelley, +16

Nature Genetics

Genome-wide Association StudyGenome-wide Directional EffectsGeneticsPolygenic RiskGenetic Epidemiology +11

KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress

Jan-Renier Moonen, James Chappell, Minyi Shi, +14

Nature Communications