Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Charles P. Fulco, Joseph Nasser, Thouis R. Jones, +16

Nature Genetics

Transcriptional RegulationNatural SciencesMolecular BiologyGene EditingGenome Editing +6

Genome-wide enhancer maps link risk variants to disease genes

Joseph Nasser, Drew T. Bergman, Charles P. Fulco, +29

Nature

Genome-wide Association StudyGeneticsRisk VariantsComplex DiseaseGenomics +1

Compatibility rules of human enhancer and promoter sequences

Drew T. Bergman, Thouis R. Jones, Vincent Liu, +12

Nature

Transcriptional RegulationCompatibility RulesGeneticsGene ExpressionMedicine +1

Convergence of coronary artery disease genes onto endothelial cell programs

Gavin R. Schnitzler, Helen Kang, Shi Fang, +24

Nature

AngiogenesisCardiovascular DiseaseNatural SciencesVascular AdaptationGene Expression +9

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

John Ray, Carl G. de Boer, Charles P. Fulco, +13

Nature Communications

HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes

Jamie L. Marshall, Benjamin R. Doughty, Vidya Subramanian, +15

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyTranscriptomics TechnologyGenomicsGene Expression Profiling +20

Cohesin-mediated 3D contacts tune enhancer-promoter regulation

Philine Guckelberger, Benjamin R. Doughty, Glen Munson, +26

GeneticsMolecular BiologyCohesin-mediated 3DEpigeneticsTranscriptional Regulation +14

Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations

Charles P. Fulco, Joseph Nasser, Thouis R. Jones, +15

EngineeringGeneticsMolecular BiologyGene CharacterizationGene Regulatory Network +18

Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi

Meghan E. Muse, Drew T. Bergman, Lucas A. Salas, +9

Journal of Investigative Dermatology

BiologyChromatinMelanocytic NeviGenomic StabilityEpigenetic Change +8

Genome-wide maps of enhancer regulation connect risk variants to disease genes

Joseph Nasser, Drew T. Bergman, Charles P. Fulco, +27

GeneticsImmunologyGene CharacterizationDisease Gene IdentificationGenomics +15