Catherine Sekerke

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

Bruce D. Roth, C. John Blankley, Alexander Chucholowski et al. · Journal of Medicinal Chemistry · 1991 · 183 citations · Full text

Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors

C L Bisgaier, Arnold D. Essenburg, Bruce J. Auerbach et al. · Journal of Lipid Research · 1997 · 72 citations · Full text

Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3<i>R</i>,5<i>R</i>)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2<i>H</i>-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia

Jeffrey A. Pfefferkorn, Chulho Choi, Scott D. Larsen et al. · Journal of Medicinal Chemistry · 2007 · 58 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Substituted Pyrazoles +15

Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

William K.C. Park, Robert M. Kennedy, Scott D. Larsen et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 55 citations · Full text

Medicinal Chemistry, Hmg-coa Reductase Inhibitors, Oxysterol +7

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn, Yuntao Song, Kuai-Lin Sun et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 55 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +5