An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, +1

Beilstein Journal of Organic Chemistry

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryChemistryHeterocycle Chemistry +16

Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

Nikzad Nikbin, Mark Ladlow, Steven V. Ley

Organic Process Research & Development

Materials ScienceChemical EngineeringCross-coupling ReactionEngineeringBottom-up Synthesis +10

Flow chemistry synthesis of zolpidem, alpidem and other GABA_Aagonists and their biological evaluation through the use of in-line frontal affinity chromatography

Lucie Guetzoyan, Nikzad Nikbin, Ian R. Baxendale, +1

Chemical Science

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryPre-clinical PharmacologySystems Pharmacology +21

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, +3

Organic & Biomolecular Chemistry

Process IntensificationFlow ChemistryEngineeringModular Flow ReactorChemical Transformation +13

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, +2

Organic & Biomolecular Chemistry

Chemical EngineeringFlow ChemistryEngineeringAcid Chloride InputsAlkene Metathesis +12

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

S. Picaud, Katharina Leonards, Jean‐Philippe Lambert, +20

Science Advances

Molecular BiologyCancer BiologyTumor BiologyTranscriptional RegulationProtein Expression +18

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, +2

Organic & Biomolecular Chemistry

Combinatorial ChemistryChemical EngineeringMedicinal ChemistryEngineeringHeterocyclic +13

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, +2

Organic & Biomolecular Chemistry

Combinatorial ChemistryChemical EngineeringMedicinal ChemistryAryl AzidesEngineering +13

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, +1

Organic & Biomolecular Chemistry

Combinatorial ChemistryFlow MicroreactorsChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +14

A Machine‐Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor‐1

Claudio Battilocchio, Benjamin J. Deadman, Nikzad Nikbin, +3

Chemistry - A European Journal

Combinatorial ChemistryDirect ComparisonOrganic ChemistryPeptide ScienceChemistry +15