Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

Cinzia Vicidomini, Luisa Ponzoni, Dmitry Lim, +14

Molecular Psychiatry

Mglu5 ReceptorsBehavioral NeuroscienceShank3 Knock-out MiceMedicineBehavioral Pharmacology +11

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N -Methyl-D-Aspartate Receptor Subunit

Alessandro Tozzi, Antonio de Iure, Vincenza Bagetta, +21

Biological Psychiatry

Synaptic PlasticityNeurodegenerative DiseasesSynaptic TransmissionNeuropharmacologyNeuroscience +7

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

Valentina Durante, Antonio de Iure, Vittorio Loffredo, +18

Brain

Synaptic TransmissionNeurochemical BiomarkersSynaptic SignalingSocial SciencesAlzheimer's Disease +16

Persistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis

Massimiliano Di Filippo, Antonio de Iure, Carmela Giampà, +12

Scientific Reports

Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

Massimiliano Di Filippo, Andrea Mancini, Laura Bellingacci, +21

Cell Reports

Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system

Alessandro Tozzi, Antonio de Iure, Michela Tantucci, +10

Frontiers in Cellular Neuroscience

Synaptic TransmissionNeurotransmitterNeurotransmissionSynaptic SignalingSocial Sciences +22

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons

Alessandro Tozzi, Valentina Durante, Paolo Manca, +6

Frontiers in Cellular Neuroscience

Synaptic TransmissionNeuroendocrinologyAndrogen ReceptorsStructural PlasticitySynaptic Signaling +16

Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis

Andrea Mancini, Michela Tantucci, Petra Mazzocchetti, +10

Neurobiology of Disease

InflammationMicroglial ActivationMitochondrial DysfunctionMedicineImmunology +10

Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease

Alessandro Tozzi, Valentina Durante, Guendalina Bastioli, +8

Neurobiology of Disease

Striatal Glutamatergic TransmissionMedicineNeuropharmacologyNeuroscienceNeurotransmission +4

Interferon-β1a modulates glutamate neurotransmission in the CNS through CaMKII and GluN2A-containing NMDA receptors

Massimiliano Di Filippo, Alessandro Tozzi, Sara Arcangeli, +5

Neuropharmacology

Interferon-β1a ModulatesSynaptic PlasticityNeurophysiologyMedicineSynaptic Transmission +12