Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

Diego F. Calvisi, Chunmei Wang, Coral Ho, +12

Gastroenterology

Tumor BiologyHepatologyHuman Hepatocellular CarcinomaMedicineLiver Physiology +10

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCFFbw7

Anders Sundqvist, Maria T. Bengoechea-Alonso, Xin Ye, +4

Cell Metabolism

BiochemistryLipid MetabolismSrebp FamilyNatural SciencesMolecular Biology +8

Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

Eva Grönroos, Ulf Hellman, Carl‐Henrik Heldin, +1

Molecular Cell

BiochemistryNatural SciencesMolecular BiologySmad7 StabilityChemical Biology

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

Eiji Furuta, Sudha K. Pai, Rui Zhan, +13

Cancer Research

Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene

Johan Ericsson, Simon Jackson, Jae Bum Kim, +2

Journal of Biological Chemistry

Metabolic RemodelingGpat PromoterCholesterol HomeostasisObesityMetabolic Syndrome +16

Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors

Valeria Giandomenico, Maria Simonsson, Eva Grünroos, +1

Molecular and Cellular Biology

Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1

Xiaoping Zhao, Daorong Feng, Qun Wang, +16

Journal of Clinical Investigation

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress

Eva Grönroos, Alexey A. Terentiev, Tanel Punga, +1

Proceedings of the National Academy of Sciences

P53 Target GenesSignaling PathwayCell RegulationMedicineNatural Sciences +11

The Balance between Acetylation and Deacetylation Controls Smad7 Stability

Maria Simonsson, Carl‐Henrik Heldin, Johan Ericsson, +1

Journal of Biological Chemistry

Molecular RegulationChemical BiologyAcetyl Transferase P300Signaling PathwayCell Regulation +17

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Yabing Mu, Reshma Sundar, Noopur Thakur, +9

Nature Communications