David Surguladze

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Rikke Holmgaard, David Schaer, Yanxia Li et al. · Journal for ImmunoTherapy of Cancer · 2018 · 358 citations · Full text

Anti–Transforming Growth Factor β Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

Zhaojing Zhong, Kyla Driscoll Carroll, Desiree Policarpio et al. · Clinical Cancer Research · 2010 · 122 citations · Full text

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy

David Schaer, Sandaruwan Geeganage, Nelusha Amaladas et al. · Clinical Cancer Research · 2019 · 121 citations

Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines

Xiaohu Ouyang, Evgueni L. Piatnitski, Vatee Pattaropong et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 98 citations

Medicinal Chemistry, Polymer-drug Conjugate, Medicine +11

Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity

Helen Kotanides, Yiwen Li, Maria Malabunga et al. · Cancer Immunology Research · 2020 · 68 citations