Discovery of 4-Benzoyl-1-[(4-methoxy-1<i>H</i>- pyrrolo[2,3-<i>b</i>]pyridin-3-yl)oxoacetyl]-2- (<i>R</i>)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions

Tao Wang, Zhongxing Zhang, Owen B. Wallace, +20

Journal of Medicinal Chemistry

Cd4-gp120 InteractionsPharmaceutical ScienceImmunologyPharmacotherapyDissolution-limited Absorption +15

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Nicholas A. Meanwell, Owen B. Wallace, Haiquan Fang, +23

Bioorganic & Medicinal Chemistry Letters

Initial SurveyMedicineHuman RetrovirusIndole Substitution PatternsImmunology +9

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

Kap-Sun Yeung, Zhilei Qiu, Quifen Xue, +15

Bioorganic & Medicinal Chemistry Letters

MedicineImmunologyAntiviral ResponseAntiviral Drug DevelopmentBioavailable Antiviral Agents +8

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

Kap-Sun Yeung, Zhilei Qiu, Zhiwei Yin, +17

Bioorganic & Medicinal Chemistry Letters

Vivo ProfilesMedicineHuman RetrovirusAntiviral Drug DevelopmentAntiviral Therapy +8

A survey of core replacements in indole-based HIV-1 attachment inhibitors

Tao Wang, Owen B. Wallace, Zhongxing Zhang, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNatural SciencesAntiviral Drug DevelopmentAntiviral Therapy +8

Development of 1<i>H</i>-Pyrazolo[3,4-<i>b</i>]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators

Matthew D. Hill, Haiquan Fang, Jeffrey M. Brown, +16

ACS Medicinal Chemistry Letters

Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship

James A. Cook, F. Christopher Zusi, Ivar M. McDonald, +32

Journal of Medicinal Chemistry

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia

Dalton King, Christiana Iwuagwu, Jim Cook, +24

ACS Medicinal Chemistry Letters

NeuropsychologyPsychotropic MedicationSynaptic TransmissionNeurotransmitterPsychopharmacology +24

Development of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists

Matthew D. Hill, Haiquan Fang, Dalton King, +19

ACS Medicinal Chemistry Letters

Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties

Matthew D. Hill, Haiquan Fang, Derek Norris, +29

ACS Medicinal Chemistry Letters