Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

Elodie M. Kuntz, Pablo Baquero, Alison M. Michie, +5

Nature Medicine

Hematological MalignancyMitochondrial FunctionMedicineMyeloid NeoplasiaStem Cell Research +7

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

Ian M. Copple, Holly K. Bryan, George T. Edge, +14

Free Radical Biology and Medicine

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

Sheela A. Abraham, Lisa Hopcroft, Emma Carrick, +15

Nature

Hematological MalignancyTumor BiologyCell TherapyMedicineMyeloid Neoplasia +9

Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

Mary T. Scott, Koorosh Korfi, Peter Saffrey, +14

Cancer Discovery

Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation

Guy Gammon, Karen Dunn, Nilabh Shastri, +3

Nature

Autoimmune DiseaseClonal InactivationT-regulatory CellImmunologyImmunogenic Peptides +8

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

Pablo Baquero, Amy Dawson, Arunima Mukhopadhyay, +17

Leukemia

Cell AutophagyMitophagyCell TherapyMedicineImmunology +5

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

Amélie V. Guitart, Chithra Subramani, Alejandro Armesilla-Diaz, +10

Blood

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

Amy Sinclair, Laura Park, Mansi Shah, +14

Blood

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy

Ross Kinstrie, Gillian A. Horne, Heather Morrison, +13

Leukemia

ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy

Angela Ianniciello, Martha M. Zarou, Kevin M. Rattigan, +12

Science Translational Medicine