Pawan K. Shahi

A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing

Guojun Chen, Amr A. Abdeen, Yuyuan Wang et al. · Nature Nanotechnology · 2019 · 349 citations

Engineering, In Vivo Gene Therapy, Vivo Genome Editing +11

A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing machineries

Yuyuan Wang, Pawan K. Shahi, Ruosen Xie et al. · Journal of Controlled Release · 2020 · 99 citations · Full text

Nanoparticles, Nanomedicine, Nanotherapeutics +12

In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles

Yuyuan Wang, Pawan K. Shahi, Xiuxiu Wang et al. · Journal of Controlled Release · 2021 · 91 citations · Full text

Nanoparticles, Engineering, Synthetic Biology +8

A Novel<i>KCNJ13</i>Nonsense Mutation and Loss of Kir7.1 Channel Function Causes Leber Congenital Amaurosis (LCA16)

Bikash R. Pattnaik, Pawan K. Shahi, Meghan J. Marino et al. · Human Mutation · 2015 · 56 citations

Genetics, Molecular Genetics, Disease Gene Identification +19

Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy

Divya Sinha, Benjamin Steyer, Pawan K. Shahi et al. · The American Journal of Human Genetics · 2020 · 51 citations · Full text

In Vivo Gene Therapy, Genetic Disorder, Medicine +7