Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition

Maria Rosaria Sapienza, Fabio Fuligni, Claudio Agostinelli, +23

Leukemia

Selective SensitivityUnique PatternImmunologyCancer GenomicsTumor Suppressor +6

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis

Valentina Corradi, Manuela Mancini, Fabrizio Manetti, +3

Bioorganic & Medicinal Chemistry Letters

Hematological MalignancyImatinib-resistant Leukemia CellsApoptosisSmall MoleculesC-abl/14-3-3 Protein–protein Interactions +6

A New Nonpeptidic Inhibitor of 14-3-3 Induces Apoptotic Cell Death in Chronic Myeloid Leukemia Sensitive or Resistant to Imatinib

Manuela Mancini, Valentina Corradi, Sara Petta, +3

Journal of Pharmacology and Experimental Therapeutics

Next-generation sequencing for sensitive detection of <i>BCR-ABL1</i> mutations relevant to tyrosine kinase inhibitor choice in imatinib-resistant patients

Simona Soverini, Caterina De Benedittis, Kateřina Machová Poláková, +15

Oncotarget

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

Marco Radi, Emmanuele Crespan, Giorgia Botta, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +7

Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case

Valentina Corradi, Manuela Mancini, Maria Alessandra Santucci, +7

Bioorganic & Medicinal Chemistry Letters

BiochemistryComputational TechniquesNatural SciencesMedicineInteractomics +10

Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway

Pier Paolo Piccaluga, Maura Rossi, Claudio Agostinelli, +17

Leukemia

ThrombopoiesisAutoimmune DiseaseBlood PlateletT-regulatory CellImmunology +8

SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis

Giovanni Martinelli, Manuela Mancini, Caterina De Benedittis, +29

Leukemia

14‐3‐3 Ligand Prevents Nuclear Import of c‐ABL Protein in Chronic Myeloid Leukemia

Manuela Mancini, Nevena Veljković, Valentina Corradi, +5

Traffic

Hematological MalignancyChromatinChronic Myeloid LeukemiaCell SignalingMedicine +13

Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells

Manuela Mancini, Sara Petta, Ilaria Iacobucci, +2

Cellular Signalling

Hematological MalignancySystems BiologyMixed-phenotype Acute LeukemiaSurvival AdvantageGene Expression +3