MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

Valentina Lucia La Rosa, Giovanna Poce, Julio Ortiz Canseco, +16

Antimicrobial Agents and Chemotherapy

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones

Daniele Castagnolo, Fabrizio Manetti, Marco Radi, +6

Bioorganic & Medicinal Chemistry

Pulmonary TuberculosisAntimicrobial Drug DiscoveryNovel Pyrazole AnaloguesMedicineMycobacterium Tuberculosis +10

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis

Daniele Castagnolo, Alessandro De Logu, Marco Radi, +7

Bioorganic & Medicinal Chemistry

Pulmonary TuberculosisNovel Pyrazole AnaloguesMedicineMycobacterium TuberculosisSar Study +8

Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity toward α₁- and α₂-Adrenoceptors

Roberta Barbaro, Laura Betti, Maurizio Botta, +6

Journal of Medicinal Chemistry

Antimycobacterial Agents. Novel Diarylpyrrole Derivatives of BM212 Endowed with High Activity toward Mycobacterium tuberculosis and Low Cytotoxicity

Mariangela Biava, Giulio Cesare Porretta, Giovanna Poce, +6

Journal of Medicinal Chemistry

Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

Giovanni Maga, Federico Falchi, Marco Radi, +16

ChemMedChem

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

Giovanna Poce, Robert H. Bates, Salvatore Alfonso, +15

PLoS ONE

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

Marco Radi, Federico Falchi, Anna Garbelli, +8

Bioorganic & Medicinal Chemistry Letters

Natural SciencesHuman RetrovirusImmunologyAntiviral Drug DevelopmentMolecular Biology +8

Pyrazolo[3,4-<i>d</i>]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation

Fabio Carraro, Antonella Naldini, Annalisa Pucci, +14

Journal of Medicinal Chemistry

ApoptosisCell DeathCellular PharmacologyCell ProliferationChemical Biology +18

Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting Activity

Antonio Solinas, Hélène Faure, Hermine Roudaut, +6

Journal of Medicinal Chemistry