Angela Skelton

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Bruce A. Malcolm, R. Liu, Frederick Lahser et al. · Antimicrobial Agents and Chemotherapy · 2006 · 316 citations · Full text

Viral Replication, Hepatitis C Virus, Immunology +17

Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034

Xinchun Tong, Robert A. Chase, Angela Skelton et al. · Antiviral Research · 2006 · 233 citations

Drug Resistance Analysis, Molecular Virology, Genetics +8

Characterization of resistance mutations against HCV ketoamide protease inhibitors

Xinchun Tong, Stéphane Bogen, Robert A. Chase et al. · Antiviral Research · 2008 · 127 citations

Drug Discovery, Resistance Mutation (Virology), Resistance Mutations +2

Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of the three poliovirus serotypes

Karen N Lentz, Allen Smith, Sheila C. Geisler et al. · Structure · 1997 · 121 citations · Full text

Virus Structure, Poliovirus Serotypes, Molecular Virology +7

Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor

MinKyung Yi, Xiao Tong, Angela Skelton et al. · Journal of Biological Chemistry · 2005 · 104 citations · Full text

Sch6 Resistance, Molecular Virology, Protease Active Site +12