Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel <i>In Vivo</i> Pharmacodynamic Assays

Mark Manfredi, Jeffrey Ecsedy, Arijit Chakravarty, +17

Clinical Cancer Research

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

Xiaohong Liu, Hong Wang, Matthias Eberstadt, +9

Cell

Nucleic Acid ChemistryBiochemistryNmr StructureNatural SciencesMolecular Biology +4

Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis

Philip J. Hajduk, Jürgen Dinges, Jeffrey M. Schkeryantz, +12

Journal of Medicinal Chemistry

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Todd B. Sells, Ryan Chau, Jeffrey Ecsedy, +16

ACS Medicinal Chemistry Letters

Aurora AImmunologyMolecular BiologyPharmacotherapyTumor Biology +17

Selective Protein Tyrosine Phosphatase 1B Inhibitors:  Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Gang Liu, Zhili Xin, Heng Liang, +13

Journal of Medicinal Chemistry

Drug TargetChemical BiologyReceptor Tyrosine KinasePotent Ptp1b InhibitorsCell Signaling +14

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Gang Liu, Bruce G. Szczepankiewicz, Zhonghua Pei, +14

Journal of Medicinal Chemistry

Compound 12DSelective Ptp1b InhibitorsChemical BiologyInsulin SignalingLeptin Signaling Pathways +15

Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905)

Matthew O. Duffey, Tricia J. Vos, Ruth Adams, +40

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryTumor BiologyMedicinal ChemistryReceptor Tyrosine Kinase +16

Design, Synthesis, and <i>in Vitro</i> Evaluation of Cyclic Nitrones as Free Radical Traps for the Treatment of Stroke

Thomas L. Fevig, Susan Bowen, David A. Janowick, +4

Journal of Medicinal Chemistry

Bioorganic ChemistryLog KLipid PeroxidationOrganic ChemistryCyclic Analog +15

CoMFA, Synthesis, and Pharmacological Evaluation of (<i>E</i>)-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1<i>H</i>-indole-2-carboxylic Acids:  3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1<i>H</i>-indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist

Bruce M. Baron, Robert J. Cregge, Robert A. Farr, +10

Journal of Medicinal Chemistry

Peptide SciencePharmacotherapyPharmaceutical ChemistrySelective AntagonistMolecular Pharmacology +17

A Method for Assigning Phenylalanines in Proteins

Hong Wang, David A. Janowick, Jeffery M. Schkeryantz, +2

Journal of the American Chemical Society

EngineeringProtein AssemblyAssigning PhenylalaninesAltmetric Attention ScoreChemical Biology +14