David A. Janowick

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel <i>In Vivo</i> Pharmacodynamic Assays

Mark Manfredi, Jeffrey Ecsedy, Arijit Chakravarty et al. · Clinical Cancer Research · 2011 · 302 citations

Medicine, Oncology, Pharmacology +14

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

Xiaohong Liu, Hong Wang, Matthias Eberstadt et al. · Cell · 1998 · 171 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +7

Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis

Philip J. Hajduk, Jürgen Dinges, Jeffrey M. Schkeryantz et al. · Journal of Medicinal Chemistry · 1999 · 119 citations · Full text

Life Sciences, Molecular Biology, Antimicrobial Resistance +16

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Todd B. Sells, Ryan Chau, Jeffrey Ecsedy et al. · ACS Medicinal Chemistry Letters · 2015 · 111 citations · Full text

Medicine, Oncology, Pharmacology +14

Selective Protein Tyrosine Phosphatase 1B Inhibitors:  Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Gang Liu, Zhili Xin, Heng Liang et al. · Journal of Medicinal Chemistry · 2003 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17