Claire Hutton

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Ian R. Hardcastle, Junfeng Liu, Eric Valeur et al. · Journal of Medicinal Chemistry · 2011 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins et al. · Journal of Medicinal Chemistry · 2006 · 147 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Imagestream detection and characterisation of circulating tumour cells – A liquid biopsy for hepatocellular carcinoma?

Laura Ogle, James Orr, Catherine E. Willoughby et al. · Journal of Hepatology · 2016 · 139 citations

Medicine, Cancer Biology, Oncology +17

Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 91 citations

Medicine, Medicinal Chemistry, Oncology +9

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions

T.J. Blackburn, Shafiq U. Ahmed, Christopher R. Coxon et al. · MedChemComm · 2013 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9