Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Gwen Lomberk, Yuna Blum, Rémy Nicolle, +30

Nature Communications

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

Rémy Nicolle, Yuna Blum, Laëtitia Marisa, +38

Cell Reports

Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype

Natalia Juiz, Abdessamad El-Kaoutari, Martin Bigonnet, +5

The FASEB Journal

Pancreatic CancerTumor HeterogeneityMedicineSingle Cell SequencingPancreatic Cancer Organoids +13

A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma

Rémy Nicolle, Odile Gayet, Pauline Duconseil, +24

Annals of Oncology

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

Rémy Nicolle, Yuna Blum, Pauline Duconseil, +22

EBioMedicine

Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer

Jérémy Guillot, Chloé Dominici, Adrien Lucchesi, +20

Nature Communications

Gene expression profiling of patient‐derived pancreatic cancer xenografts predicts sensitivity to the <scp>BET</scp> bromodomain inhibitor <scp>JQ</scp> 1: implications for individualized medicine efforts

Benjamin Bian, Martin Bigonnet, Odile Gayet, +25

EMBO Molecular Medicine

A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis

Yousra Mohamed Abd-El-Halim, Abdessamad El Kaoutari, Françoise Silvy, +8

EBioMedicine

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

Wenjun Lan, Benjamin Bian, Yi Xia, +8

Scientific Reports

Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi)

Benjamin Bian, Natalia Juiz, Odile Gayet, +7

Frontiers in Oncology