Sophie M. Poznanski

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

Sophie M. Poznanski, Kanwaldeep Singh, Tyrah M. Ritchie et al. · Cell Metabolism · 2021 · 253 citations · Full text

Tumor Biology, Cancer Immunosurveillance, Medicine +10

M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner

Tamara Krneta, Amy Gillgrass, Sophie M. Poznanski et al. · Journal of Leukocyte Biology · 2016 · 108 citations

IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation

Evan Lusty, Sophie M. Poznanski, Karen Kwofie et al. · Molecular Immunology · 2017 · 88 citations

Inflammation, Cytokine, Immune Cell Development +11

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

Ana L. Portillo, Richard T. Hogg, Sophie M. Poznanski et al. · iScience · 2021 · 67 citations · Full text

Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model

Sophie M. Poznanski, Tina Nham, Marianne V. Chew et al. · Cancer Immunology Research · 2018 · 56 citations · Full text