Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B. Baell, David J. Leaver, S.J. Hermans, +49

Nature

Cancer ResearchChromatinTumour GrowthChromatin RemodelingMedicine +10

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, +30

Cell

Cancer ResearchSignal TransductionSignaling PathwayMedicineCancer Genomics +7

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

Ralph K. Lindemann, Andrea Newbold, Kate F. Whitecross, +14

Proceedings of the National Academy of Sciences

ImmunologyPathologyCell DeathTumor BiologyHematological Malignancy +16

A Central Role for Bid in Granzyme B-induced Apoptosis

Nigel J. Waterhouse, Karin Sedelies, Kylie A. Browne, +9

Journal of Biological Chemistry

MitophagyCentral RoleMitochondrial FunctionGranzyme B-induced ApoptosisApoptosis +12

The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

Leigh Ellis, Michael Bots, Ralph K. Lindemann, +8

Blood

Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

Kate F. Whitecross, Amber E. Alsop, Leonie A. Cluse, +7

Blood

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Simon J. Hogg, Andrea Newbold, Stephin J. Vervoort, +9

Molecular Cancer Therapeutics

Aggressive B-cell LymphomaApoptosisImmunologyCell DeathImmunotherapy +17

Suppression of behavioural and physiological oestrus in the mare by vaccination against GnRH

Martin J. Elhay, Andrea Newbold, AA Britton, +3

Australian Veterinary Journal

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD–Driven Acute Myeloid Leukemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, +13

Cancer Discovery

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

Andrea Newbold, Ralph K. Lindemann, Leonie A. Cluse, +3

Molecular Cancer Therapeutics