Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin

Stuart Bevan, Sandeep S Hothi, Glyn A. Hughes, +5

British Journal of Pharmacology

Competitive AntagonismNeurotransmitterCompetitive AntagonistPharmacotherapyNeurotransmission +16

The Discovery of Capsazepine, the First Competitive Antagonist of the Sensory Neuron Excitants Capsaicin and Resiniferatoxin

Christopher Walpole, Stuart Bevan, G. Bovermann, +8

Journal of Medicinal Chemistry

Pain MedicineNeurotransmitterAnesthetic MechanismMolecular PainCapsaicin Analogues +15

Bradyzide, a potent non‐peptide B₂ bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia

Gillian M. Burgess, Martin Perkins, H P Rang, +17

British Journal of Pharmacology

2-Nitrophenylcarbamoyl-(<i>S</i>)-prolyl-(<i>S</i>)-3-(2-naphthyl)alanyl-<i>N</i>-benzyl-<i>N</i>- methylamide (SDZ NKT 343), a Potent Human NK₁ Tachykinin Receptor Antagonist with Good Oral Analgesic Activity in Chronic Pain Models

Christopher Walpole, Sun Young Ko, Michael C. Brown, +9

Journal of Medicinal Chemistry

Pain DisordersPain MedicineBenzylthiourea SubstituentNeuropathic PainMolecular Pain +21

Analogues of Capsaicin with Agonist Activity as Novel Analgesic Agents:  Structure−Activity Studies. 4. Potent, Orally Active Analgesics

Roger Wrigglesworth, Christopher Walpole, Stuart Bevan, +6

Journal of Medicinal Chemistry

Pharmaceutical SciencePain MedicineActive AnalgesicsPharmacotherapyPharmaceutical Chemistry +16

Identification and Biological Characterization of 6-Aryl-7-isopropylquinazolinones as Novel TRPV1 Antagonists that Are Effective in Models of Chronic Pain

Andrew J. Culshaw, Stuart Bevan, Martin Lau Christiansen, +24

Journal of Medicinal Chemistry

Pain TherapyNovel Trpv1Pain MedicineTrpv1 AntagonistsHigh Throughput +18

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Darren Le Grand, Martin Gosling, Urs Baettig, +41

Journal of Medicinal Chemistry

1-(2-Nitrophenyl)thiosemicarbazides:  A Novel Class of Potent, Orally Active Non-Peptide Antagonist for the Bradykinin B₂ Receptor

Edward K. Dziadulewicz, Timothy J. Ritchie, Allan Hallett, +15

Journal of Medicinal Chemistry

Altmetric Attention ScorePeptide SciencePharmacotherapyExperimental PharmacologyTranslational Pharmacology +15

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

Frank Narjes, Antonio Llinàs, Stefan von Berg, +24

Journal of Medicinal Chemistry

Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism

Lena Ripa, Jenny Sandmark, Glyn A. Hughes, +14

Journal of Medicinal Chemistry

Chemoprevention StrategySubstrate InhibitorsTheir Bioactivation MechanismHdac FamilyChemical Biology +20