Lake Ee Khaw

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

Torsten Schwecke, Jesús F. Aparicio, István Molnár et al. · Proceedings of the National Academy of Sciences · 1995 · 447 citations · Full text

Systems Biology, Biosynthesis, Engineering +14

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase

Jesús F. Aparicio, István Molnár, Torsten Schwecke et al. · Gene · 1996 · 242 citations

Biosynthesis, Engineering, Cellular Enzymology +9

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases

Stephen Haydock, Jesús F. Aparicio, István Molnár et al. · FEBS Letters · 1995 · 241 citations · Full text

Engineering, Molecular Biology, Escherichia Coli +16

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase

István Molnár, Jesús F. Aparicio, Stephen Haydock et al. · Gene · 1996 · 145 citations · Full text

Biosynthesis, Engineering, Biosynthetic Gene Cluster +10

Mutational Biosynthesis of Novel Rapamycins by a Strain of <i>Streptomyces hygroscopicus</i> NRRL 5491 Disrupted in <i>rapL</i> , Encoding a Putative Lysine Cyclodeaminase

Lake Ee Khaw, Günter A. Böhm, Su Metcalfe et al. · Journal of Bacteriology · 1998 · 91 citations · Full text