Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

Cullen L. Schmid, Nicole Kennedy, Nicolette C. Ross, +6

Cell

Opioid EpidemicSubstance AbuseHealth SciencesMedicineAddiction +12

Reactive Oxygen and Targeted Antioxidant Administration in Endothelial Cell Mitochondria

Yunxia O’Malley, Brian D. Fink, Nicolette C. Ross, +2

Journal of Biological Chemistry

Lipid PeroxidationChemical BiologyReactive Oxygen SpeciesRedox BiologyOxidative Stress +17

Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias

Nicole Kennedy, Cullen L. Schmid, Nicolette C. Ross, +6

Journal of Medicinal Chemistry

Piperidine Benzimidazolone MorPain MedicineMolecular PainPharmacotherapyMolecular Pharmacology +18

Novel opioid cyclic tetrapeptides: Trp isomers of CJ‐15,208 exhibit distinct opioid receptor agonism and short‐acting κ opioid receptor antagonism

Nicolette C. Ross, Kate J. Reilley, Thomas F. Murray, +2

British Journal of Pharmacology

Physical Presence of Nor-Binaltorphimine in Mouse Brain over 21 Days after a Single Administration Corresponds to Its Long-Lasting Antagonistic Effect on κ-Opioid Receptors

Kshitij A. Patkar, Jinhua Wu, Michelle L. Ganno, +5

Journal of Pharmacology and Experimental Therapeutics

The Macrocyclic Peptide Natural Product CJ-15,208 Is Orally Active and Prevents Reinstatement of Extinguished Cocaine-Seeking Behavior

Jane V. Aldrich, Sanjeewa N. Senadheera, Nicolette C. Ross, +3

Journal of Natural Products

Cocaine-seeking BehaviorPharmacotherapyAntagonist ActivityPrevents ReinstatementMedicinal Chemistry +15

Unexpected Opioid Activity Profiles of Analogues of the Novel Peptide Kappa Opioid Receptor Ligand CJ‐15,208

Jane V. Aldrich, Santosh S. Kulkarni, Sanjeewa N. Senadheera, +6

ChemMedChem

Reactions of some cyclopentenones with selected cysteine derivatives and biological activities of the product thioethers

J.F. Bickley, Alessandra Ciucci, P. Andrew Evans, +3

Bioorganic & Medicinal Chemistry

Bioorganic ChemistryProduct ThioethersBiochemistryHeterocyclicNatural Sciences +6

Synthesis of CJ-15,208, a novel κ-opioid receptor antagonist

Nicolette C. Ross, Santosh S. Kulkarni, Jay P. McLaughlin, +1

Tetrahedron Letters

Molecular PharmacologyMedicineMechanism Of ActionPharmacological AgentNeuropharmacology +3

Alanine analogues of [<scp>D</scp>‐<scp>T</scp>rp]<scp>CJ</scp>‐15,208: novel opioid activity profiles and prevention of drug‐ and stress‐induced reinstatement of cocaine‐seeking behaviour

Jane V. Aldrich, Sanjeewa N. Senadheera, Nicolette C. Ross, +5

British Journal of Pharmacology