In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor

Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig, +3

Journal of Pharmacology and Experimental Therapeutics

Roflumilast Fully Prevents Emphysema in Mice Chronically Exposed to Cigarette Smoke

Piero A. Martorana, Rolf Beume, Monica Lucattelli, +2

American Journal of Respiratory and Critical Care Medicine

Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma

Rakesh Kumar, Cristan Herbert, Paul S. Thomas, +5

Journal of Pharmacology and Experimental Therapeutics

Roflumilast N‐oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke<i>in vitro</i>

Javier Milara, M Armengot, P Bañuls, +4

British Journal of Pharmacology

The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice

S. Vollert, N. Kaessner, Anke Heuser, +6

Diabetologia

Pde4 InhibitorsGlucose-lowering EffectsBiochemistryMedicineDiabetes +5

Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors

Lutz Wollin, Daniela S. Bundschuh, Andrea Wohlsen, +2

Pulmonary Pharmacology & Therapeutics

AsthmaInflammationAnti-inflammatoryInflammatory Lung DiseasePulmonary Inflammation +7

Zardaverine: a cyclic AMP specific PDE III/IV inhibitor.

Christian Schudt, Susanne Winder, Manfrid Eltze, +2

PubMed

Molecular PharmacologyAllergyBiochemistryPde IiiMedicine +10

Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice

Piero A. Martorana, Benedetta Lunghi, Monica Lucattelli, +3

BMC Pulmonary Medicine

A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro

Federica Sabatini, Loredana Petecchia, Silvia Boero, +6

Pulmonary Pharmacology & Therapeutics

AsthmaInflammationFibrosisAntifibrotic TherapyInflammatory Lung Disease +12

Roflumilast inhibits leukocyte–platelet interactions and prevents the prothrombotic functions of polymorphonuclear leukocytes and monocytes

Licia Totani, Concetta Amore, A. Di Santo, +6

Journal of Thrombosis and Haemostasis

InflammationRoflumilast InhibitsProthrombotic FunctionsAnti-inflammatoryBlood Platelet +9