Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

Eckard Hamelmann, Jürgen Schwarze, Katsuyuki Takeda et al. · American Journal of Respiratory and Critical Care Medicine · 1997 · 1.3K citations

Life Sciences, Immunology, Pharmacology +16

Clinical Control and Histopathologic Outcome of Asthma when Using Airway Hyperresponsiveness as an Additional Guide to Long-Term Treatment

Jacob K. Sont, Elisabeth H. Bel, J.H.J.M. van Krieken et al. · American Journal of Respiratory and Critical Care Medicine · 1999 · 895 citations

Pharmacy, Internal Medicine, Pharmacotherapy +14

Airway Wall Thickness in Asthma Assessed by Computed Tomography

Akio Niimi, Hisako Matsumoto, Ryoichi Amitani et al. · American Journal of Respiratory and Critical Care Medicine · 2000 · 398 citations

Medicine, Internal Medicine, Pulmonary Function Testing +16

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro

Armin Hatzelmann, Christian Schudt · Journal of Pharmacology and Experimental Therapeutics · 2001 · 398 citations

Medicine, Medicinal Chemistry, Pharmacology +10

An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen

Jason Temelkovski, Simon P. Hogan, D.P. Shepherd et al. · Thorax · 1998 · 331 citations · Full text

Life Sciences, Immunology, Pathobiology +17