Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Sangjune Kim, Seung‐Hwan Kwon, Tae‐In Kam, +16

Neuron

Transneuronal PropagationNeurodegenerative DiseasesSynaptic SignalingSynaptic TransmissionDegenerative Pathology +8

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Seung Pil Yun, Tae‐In Kam, Nikhil Panicker, +30

Nature Medicine

Neurodegenerative DiseasesMedicineA1 Astrocyte ConversionParkinson ’Brain-immune Interaction +7

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Donghoon Kim, Je Min Yoo, Heehong Hwang, +19

Nature Nanotechnology

Neurodegenerative DiseasesGraphene Quantum DotGrapheneNeurologyNeurodegeneration +2

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Jong Sung Park, Tae‐In Kam, Saebom Lee, +17

Acta Neuropathologica Communications

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Sangjune Kim, Seung Pil Yun, Saebom Lee, +14

Proceedings of the National Academy of Sciences

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Seung Pil Yun, Donghoon Kim, Sangjune Kim, +12

Molecular Neurodegeneration

c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential

Saurav Brahmachari, Senthilkumar S. Karuppagounder, Preston Ge, +4

Journal of Parkinson s Disease

Therapeutic PotentialApoptosisCell DeathNeurochemical BiomarkersSynaptic Signaling +20

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model

Saebom Lee, Sangjune Kim, Yong Joo Park, +14

Human Molecular Genetics

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease

Saurav Brahmachari, Saebom Lee, Sangjune Kim, +19

Brain

TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

Bo Am Seo, Donghoon Kim, Heehong Hwang, +27

Neuron

Neurodegenerative DiseasesTrip12 UbiquitinationBiochemistryDegenerative PathologyNeuroprotection +6