Sean Yu McLoughlin

Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution

Huajie Yang, Paul D. Carr, Sean Yu McLoughlin et al. · Protein Engineering Design and Selection · 2003 · 160 citations · Full text

Biosynthesis, Biochemistry, Bioenergetics +15

A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

Sean Yu McLoughlin, Shelley D. Copley · Proceedings of the National Academy of Sciences · 2008 · 88 citations · Full text

Differential Effects of a Mutation on the Normal and Promiscuous Activities of Orthologs: Implications for Natural and Directed Evolution

Akhil Khanal, Sean Yu McLoughlin, Jamie P. Kershner et al. · Molecular Biology and Evolution · 2014 · 78 citations · Full text

Genetics, Molecular Biology, Natural Selection +24

Growth of <i>Escherichia coli</i> Coexpressing Phosphotriesterase and Glycerophosphodiester Phosphodiesterase, Using Paraoxon as the Sole Phosphorus Source

Sean Yu McLoughlin, Colin J. Jackson, Jianwei Liu et al. · Applied and Environmental Microbiology · 2004 · 72 citations · Full text

A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate

Jamie P. Kershner, Sean Yu McLoughlin, Juhan Kim et al. · Journal of Bacteriology · 2016 · 49 citations · Full text