Chuan’ai Chen

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

Chuan’ai Chen, Dekun Wang, Yangyang Yu et al. · Cell Death and Disease · 2021 · 273 citations · Full text

Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B

Jing Xun, Lingfang Du, Ruifang Gao et al. · Theranostics · 2021 · 149 citations · Full text

Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy

Dekun Wang, Min Xiong, Chuan’ai Chen et al. · Kidney International · 2018 · 60 citations

Inflammation, Glomerular Disease, Urology +13

Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation

Long Shen, Lichun Kang, Dekun Wang et al. · Cancer Letters · 2019 · 37 citations

Inflammation, Cytokine, Medicine +12

Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis

Dekun Wang, Lichun Kang, Chuan’ai Chen et al. · Aging Cell · 2022 · 27 citations · Full text