Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B

Jing Xun, Lingfang Du, Ruifang Gao, +11

Theranostics

Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

Long Shen, Penghui Hu, Yanan Zhang, +17

Cell Metabolism

Antiviral Innate ImmunityViral ImmunityImmunologyPathogenesisViral Pathogenesis +7

Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis

Xiao Shan, Penghui Hu, Lina Ni, +14

Cellular and Molecular Immunology

Signal TransductionSignaling PathwaySerine MetabolismMedicineMetabolic Signaling +5

M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma

Long Shen, Honghao Li, Yuzhi Shi, +6

Scientific Reports

Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2

Yu Wang, Binhui Xie, Weihao Lin, +9

Oncogene

HepatologyMedicinePathologyIntrahepatic MetastasisLiver Cancer +6

JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity

Jing Xun, Dekun Wang, Long Shen, +7

Oncotarget

Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation

Long Shen, Lichun Kang, Dekun Wang, +12

Cancer Letters

InflammationCytokineMedicineImmunologyLegumain-deficient Macrophages +10

JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms

Yan Zhang, Long Shen, Dwayne G. Stupack, +8

Oncotarget

Distinct MechanismsImmunologyPathologyImmunologic MechanismImmunotherapy +15

Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model

Xue Mi, Haiqiao Du, Xinmeng Guo, +12

Acta Biomaterialia

NanomedicineNeurodegenerative DiseasesAlzheimer's DiseaseDisease ModelMolecular Biology +5

MTHFD2 reprograms macrophage polarization by inhibiting PTEN

Man Shang, Lina Ni, Xiao Shan, +9

Cell Reports