Aamir S. Mukadam

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

Anne Rovelet‐Lecrux, Camille Charbonnier, David Wallon et al. · Molecular Psychiatry · 2015 · 104 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Deleterious Genetic Variations +10

Target-induced clustering activates Trim-Away of pathogens and proteins

Jingwei Zeng, Ana Filipa Santos, Aamir S. Mukadam et al. · Nature Structural & Molecular Biology · 2021 · 95 citations · Full text

Virulence Factor, Pathogenesis, Computational Biology +4

Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex

Matthew Seaman, Aamir S. Mukadam, Sophia Y. Breusegem · Journal of Cell Science · 2018 · 79 citations · Full text

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models

Aamir S. Mukadam, Lauren V. C. Miller, Annabel E. Smith et al. · Science · 2023 · 71 citations · Full text

Tau Pathology, Immunology, Immunodominance +18

The Immune System GTPase GIMAP6 Interacts with the Atg8 Homologue GABARAPL2 and Is Recruited to Autophagosomes

John C. Pascall, Sergio Rotondo, Aamir S. Mukadam et al. · PLoS ONE · 2013 · 26 citations · Full text

Mitophagy, Immune Systems, Laboratory Immunology +21