NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, +107

Nature

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Monika Wolf, Arlind Adili, Kira Piotrowitz, +24

Cancer Cell

InflammationHepatologyHepatocellular CarcinomaMetabolic ActivationLiver Physiology +9

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

Monica Yabal, Nicole Müller, Heiko Adler, +13

Cell Reports

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

Detian Yuan, Shan Huang, Emanuel Berger, +40

Cancer Cell

Chronic Mitochondrial DysfunctionMitochondrial FunctionBiliary CancerLiver PhysiologyImmunology +7

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

Roman Maresch, Sebastian Mueller, Christian Veltkamp, +26

Nature Communications

Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells

Martin F. Sprinzl, Florian Reisinger, Andreas S. Puschnik, +11

Hepatology

Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation

Nora Hagemeyer, Katrin Kierdorf, Kathrin Frenzel, +12

The EMBO Journal

Transcriptional RegulationDevelopmental BiologySignaling PathwayImmune Cell DevelopmentInnate Immune System +6

Lineage fate of ductular reactions in liver injury and carcinogenesis

Simone Jörs, Petia Jeliazkova, Marc Ringelhan, +8

Journal of Clinical Investigation

PathologyOrgan DevelopmentCholangiopathiesCholangiocyte BiologyTumor Biology +23

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

Thomas Michler, Anna D. Kosinska, Julia Festag, +14

Gastroenterology

VaccinationVaccine DevelopmentViral HepatitisVaccine TargetImmunology +6

microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis

Sanchari Roy, Guido Hooiveld, Marco Seehawer, +22

Gastroenterology

Developmental BiologySpindle-associated Protein 1Liver PhysiologyRna BiologyMicrorna Detection +8