Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic Progression

Lora C. Bailey‐Downs, Jessica E. Thorpe, Bryan C. Disch, +6

PLoS ONE

Surgical OncologyBreast OncologyNatural MetastasisImmunologyBiological Microenvironments +19

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents

Xin Zhang, Sudhir Raghavan, Michael A. Ihnat, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryDrug TargetBiochemistryAntitumor AgentsNatural Sciences +7

Discovery of Antitubulin Agents with Antiangiogenic Activity as Single Entities with Multitarget Chemotherapy Potential

Aleem Gangjee, Roheeth K. Pavana, Michael A. Ihnat, +6

ACS Medicinal Chemistry Letters

PharmacotherapyTumor BiologySingle EntitiesMultitarget Chemotherapy PotentialMetronomic Therapy +17

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

Anja Bastian, Satoshi Matsuzaki, Kenneth M. Humphries, +5

Cancer Letters

Redox SignalingMolecular PharmacologyRedox RegulatorMedicineHypoxia (Medicine) +10

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents

Xin Zhang, Sudhir Raghavan, Michael A. Ihnat, +5

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences +8

Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia

Eric G. Lee, Lerin R. Luckett‐Chastain, Kaitlin Calhoun, +3

Journal of Immunology Research

A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer

Anja Bastian, Jessica E. Thorpe, Bryan C. Disch, +7

Journal of Pharmacology and Experimental Therapeutics

Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents

Aleem Gangjee, Nilesh Zaware, Sudhir Raghavan, +4

Bioorganic & Medicinal Chemistry

Biological ActivityAntiangiogenic AgentsBiochemistryMedicineNatural Sciences +5

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

Roheeth K. Pavana, Shruti Choudhary, Anja Bastian, +4

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPreclinical EvaluationAntitumor AgentsMedicineSingle Agents +7

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

Nilesh Zaware, Roy L. Kisliuk, Anja Bastian, +2

Bioorganic & Medicinal Chemistry Letters