Toshihito Hiroi

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

Shinichiro Yamamoto, Shunichi Shimizu, Shigeki Kiyonaka et al. · Nature Medicine · 2008 · 612 citations · Full text

Inflammation, Inflammatory Neutrophil Infiltration, Cytokine +12

Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury

Toshihito Hiroi, Teruaki Wajima, Takaharu Negoro et al. · Cardiovascular Research · 2012 · 116 citations

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells

Shunichi Shimizu, Toshihito Hiroi, Masakazu Ishii et al. · The International Journal of Biochemistry & Cell Biology · 2007 · 35 citations

Inflammation, Signal Transduction, Biochemistry +14

Reduction of Myocardial Infarct Size by Tetrahydrobiopterin: Possible Involvement of Mitochondrial KATP Channels Activation through Nitric Oxide Production

Teruaki Wajima, Shunichi Shimizu, Toshihito Hiroi et al. · Journal of Cardiovascular Pharmacology · 2006 · 15 citations

Heart Failure, Intravenous Administration, Pharmacotherapy +18

Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload

Shunichi Shimizu, Masaaki Ishibashi, Sumito Kumagai et al. · International Journal of Molecular Medicine · 2013 · 15 citations · Full text

Cardiac Muscle, Heart Failure, Mitochondrial Dysfunction +18