Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

Giovanni Monaco, Elke Decrock, H Akl, +10

Cell Death and Differentiation

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2

Haidar Akl, Giovanni Monaco, Rita La Rovere, +10

Cell Death and Disease

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Maarten De Smet, Alessio Lissoni, Timur Nezlobinsky, +14

Journal of Clinical Investigation

Cardiac MuscleBiomedical EngineeringCell JunctionsCellular PhysiologyCx43 Hemichannel Microdomain +14

Bcl-2 binds to and inhibits ryanodine receptors

Tim Vervliet, Elke Decrock, Jordi Molgó, +7

Journal of Cell Science

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

Katrien Neyrinck, Johanna Van Den Daele, Tim Vervliet, +17

Stem Cell Reviews and Reports

Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain

Tim Vervliet, Irma Lemmens, Elien Vandermarliere, +12

Scientific Reports

ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome

Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, +19

Nature Communications

Basal ryanodine receptor activity suppresses autophagic flux

Tim Vervliet, Isabel Pintelon, Kirsten Welkenhuyzen, +7

Biochemical Pharmacology

Molecular PhysiologyNeurophysiologyAutophagic FluxPhysiologyNeurotransmitter +2

Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression

Vittoria Marini, Fabiola Marino, Flaminia Aliberti, +10

Frontiers in Cell and Developmental Biology

Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function

Sander Craps, Jore Van Wauwe, Sofie De Moudt, +13

Circulation Research

Visual LanguageCardiovascular DiseaseVascular AdaptationPhysiologyGraphic Design +7