Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Alexander Gillis, Arisbel B. Gondin, Andrea Kliewer, +19

Science Signaling

Biased AgonismOpioid EpidemicPain MedicineMolecular PainLow Intrinsic Efficacy +21

Ticks from diverse genera encode chemokine-inhibitory evasin proteins

Jenni A. Hayward, Julie Sanchez, Andrew Perry, +5

Journal of Biological Chemistry

ProteomicsBioinformaticsProtein ExpressionSystems Biology

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Zil E Huma, Julie Sanchez, Herman D. Lim, +9

Science Signaling

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

David J. Leaver, Benjamin Cleary, Nghi Nguyen, +27

Journal of Medicinal Chemistry

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

J. Robert Lane, Ara M. Abramyan, Pramisha Adhikari, +8

eLife

Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES

Xiaoyi Wang, Julie Sanchez, Martin J. Stone, +1

Angewandte Chemie International Edition

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

Julie Sanchez, Zil E Huma, J. Robert Lane, +5

Journal of Biological Chemistry

Chemokine Receptor Ccr1Chemokine BiologySignal TransductionBiochemistryG Protein-coupled Receptor +10

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Daniel L. Priebbenow, David J. Leaver, Nghi Nguyen, +30

Journal of Medicinal Chemistry

Novel Dual-Target μ-Opioid Receptor and Dopamine D₃ Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management

Alessandro Bonifazi, Francisco O. Battiti, Julie Sanchez, +11

Journal of Medicinal Chemistry

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

Julie Sanchez, J. Robert Lane, Meritxell Canals, +1

International Journal of Molecular Sciences

Biased AgonismChemokine Receptor Ccr1Chemokine BiologyImmunologyImmune Regulation +24