Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

Daniel Nagel, Stefani Spranger, Michelle Vincendeau, +12

Cancer Cell

Medicinal ChemistryBiochemistryPharmacologic InhibitionNatural SciencesMedicine +6

Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells

Bernhard Kloo, Daniel Nagel, Matthias Pfeifer, +7

Proceedings of the National Academy of Sciences

Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

Daniela Cornacchia, Chao Zhang, Bastian Zimmer, +15

Cell stem cell

Naive-to-primed Intermediate StateSignal TransductionPhysiologyLipid DeprivationHuman Pscs +9

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

Florian Schlauderer, Katja Lammens, Daniel Nagel, +8

Angewandte Chemie International Edition

Crystal StructureSecond SiteImmunologyPathologyPhenothiazine Derivatives +19

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

Juliane Tschuck, Lea Theilacker, Ina Rothenaigner, +12

Nature Communications

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

Jara Kerstin Brenke, Grzegorz M. Popowicz, Kenji Schorpp, +12

Journal of Biological Chemistry

Autoimmune DiseaseImmunologyImmunologic MechanismAutoimmunityAutoantibodies +6

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

Michelle Vincendeau, Ingmar Göttesdorfer, Julia Schreml, +9

Retrovirology

Expression of Human Endogenous Retrovirus-W Including Syncytin-1 in Cutaneous T-Cell Lymphoma

Pilvi Maliniemi, Michelle Vincendeau, Jens Mayer, +8

PLoS ONE

Cutaneous T-cell LymphomaLymphoid NeoplasiaMf Lymphoma CellsAutoimmune DiseaseMycosis Fungoides +11

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

Vidya Padmanabhan Nair, Hengyuan Liu, Gabriele Ciceri, +16

Cell stem cell

Cortical PatterningDevelopmental BiologyMolecular NeuroscienceNeurophysiologyNeuronal Differentiation +10

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas

Miriam Bognar, Michelle Vincendeau, Tabea Erdmann, +10

Oncogene