Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

Sherif Ibrahim, Ramy Gadalla, Eslam A. Elghonaimy, +7

Molecular Cancer

Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials

Ramy Gadalla, Babak Noamani, Bethany MacLeod, +14

Frontiers in Oncology

The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

Sabelo Lukhele, Diala Abd Rabbo, Mengdi Guo, +17

Immunity

Cancer ImmunosurveillanceImmunologyTumor ImmunityImmunologic MechanismAutoimmunity +7

Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-β-catenin signalling, the stem cell phenotype and disease progression

Hossam Taha Mohamed, Ramy Gadalla, Noura El-Husseiny, +6

Journal of Advanced Research

Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer

Stéphanie Lheureux, Daniela Matei, Panagiotis A. Konstantinopoulos, +23

Journal for ImmunoTherapy of Cancer

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

Derek Clouthier, Scott Lien, S.Y. Cindy Yang, +30

Journal for ImmunoTherapy of Cancer

Tumor microenvironmental plasmacytoid dendritic cells contribute to breast cancer lymph node metastasis via CXCR4/SDF-1 axis

Ramy Gadalla, Hebatallah Hassan, Sherif Ibrahim, +6

Breast Cancer Research and Treatment

Breast OncologyMedicineImmunologyBreast CancerDendritic Cell Biology +5

Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy

Giselle M. Boukhaled, Ramy Gadalla, Heidi Elsaesser, +21

Nature Immunology

Autoimmune DiseasePre-encoded ResponsivenessImmunologyImmunologic MechanismAutoimmunity +9

The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients

Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, +5

PLoS ONE

T-regulatory CellImmunologyImmune RegulationTh2 SubsetsImmunoediting +19

Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Scott Lien, Dalam Ly, S.Y. Cindy Yang, +13

Nature Communications