Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

Luca Gattinoni, Xiaosong Zhong, Douglas C. Palmer, +10

Nature Medicine

T Cell DifferentiationMedicineAdult Stem CellImmunologyStem Cell Research +5

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Xianwen Ren, Wen Wen, Xiaoying Fan, +87

Cell

Single Cell SequencingMedicineImmunologySingle-cell GenomicsChronic Viral Infection +3

G₁ cell cycle progression and the expression of G₁ cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells

Ning Gao, Daniel C. Flynn, Zhuo Zhang, +5

American Journal of Physiology-Cell Physiology

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

Yangbing Zhao, Qiong J. Wang, Shicheng Yang, +7

The Journal of Immunology

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling

Yong Qian, Xiaosong Zhong, Daniel C. Flynn, +6

Oncogene

Signal TransductionSignaling PathwayCell SignalingCell MigrationCytoskeleton +5

Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C.

Chuanshu Huang, Jingxia Li, Qingdong Ke, +6

PubMed

Molecular BiologyCell DeathRedox BiologyOxidative StressMammalian Target +18

Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort

Lijun Wu, Xiangzhu Zhu, Lei Fan, +8

Scientific Reports

SU5416 inhibited VEGF and HIF-1α expression through the PI3K/AKT/p70S6K1 signaling pathway

Xiaosong Zhong, Jenny Z. Zheng, Eddie Reed, +1

Biochemical and Biophysical Research Communications

Signal TransductionSignaling PathwayHif-1α ExpressionSystems BiologyMedicine +4

MZF1 possesses a repressively regulatory function in ERCC1 expression

Qing-Wu Yan, Eddie Reed, Xiaosong Zhong, +3

Biochemical Pharmacology

Transcriptional RegulationSignal TransductionMolecular RegulationGene RegulationErcc1 Expression +5

Antitumor activity of the third generation EphA2 CAR-T cells against glioblastoma is associated with interferon gamma induced PD-L1

Zhijing An, Yi Hu, Yue Bai, +6

OncoImmunology

Antitumor ActivityImmunologyImmune RegulationImmunoeditingImmunologic Mechanism +17