Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates

Brian C. Beard, Grant D. Trobridge, Christina Ironside, +3

Journal of Clinical Investigation

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2

Olivier Humbert, George S. Laszlo, Sophie R Sichel, +7

Leukemia

Genome SurgeryImmunologyNormal HematopoiesisGene EditingGenome Editing +6

Cocal-pseudotyped Lentiviral Vectors Resist Inactivation by Human Serum and Efficiently Transduce Primate Hematopoietic Repopulating Cells

Grant D. Trobridge, R. Alex Wu, Michael J. Hansen, +5

Molecular Therapy

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice

Anne-Sophie Kuhlmann, Kevin G. Haworth, Isaac Barber-Axthelm, +4

Molecular Therapy

MedicineHuman RetrovirusImmunologyBlood CellAntiviral Response +7

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Meera Srikanthan, Olivier Humbert, Kevin G. Haworth, +8

Molecular Therapy — Methods & Clinical Development

Knockout MouseImmunogeneticsCell TherapyImmunologyHematology +7

Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

Brian C. Beard, Reeteka Sud, Kirsten A. Keyser, +5

Blood

Stem Cell Selection In Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency

Grant D. Trobridge, Brian C. Beard, R. Alex Wu, +3

PLoS ONE

Foamy and Lentiviral Vectors Transduce Canine Long-Term Repopulating Cells at Similar Efficiency

Grant D. Trobridge, James M. Allen, Laura J. Peterson, +3

Human Gene Therapy

Similar EfficiencyCell TherapyDog ModelImmunologyCell Culture +15

HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways

Kevin G. Haworth, Lauren E. Schefter, Zachary K. Norgaard, +3

JCI Insight

Viral ReplicationViral Polymerase MechanismPathogenesis-related Biological PathwaysImmunologyViral Dynamic +19

In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model

Jennifer L. Gori, Breanna Beard, Christina Ironside, +2

Cancer Gene Therapy

Cell TherapyDog ModelMedicineImmunologyVivo Selection +7