Teresa Mulder

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

Richard Graham, Bert L. Lum, Glenn Morrison et al. · Drug Metabolism and Disposition · 2011 · 59 citations

Medicine, Oncology, Pharmacology +15

Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease

Jack A. Terrett, Justin Q. Ly, Paula Katavolos et al. · Journal of Medicinal Chemistry · 2024 · 21 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening

Qin Yue, Yung‐Hsiang Chen, Teresa Mulder et al. · Drug Metabolism and Disposition · 2011 · 16 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes

Wei Wang, Teresa Mulder, Jingwei Cai et al. · Xenobiotica · 2020 · 12 citations · Full text

Pharmacy, Pharmacokinetics, Toxicology +14

Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib

S. Cyrus Khojasteh, Qin Yue, Shuguang Ma et al. · Drug Metabolism and Disposition · 2014 · 10 citations

Medicine, Oncology, Pharmacology +17