Laykea Tafesse

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy

Kenneth J. Valenzano, Laykea Tafesse, Gary Lee et al. · Neuropharmacology · 2005 · 285 citations

Medicine, Pharmacokinetics, Pharmacology +13

N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2 H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties

Kenneth J. Valenzano, Elfrida R. Grant, Gang Wu et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 249 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

4-(2-Pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists

Qun Sun, Laykea Tafesse, Khondaker Islam et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 50 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists

Laykea Tafesse, Qun Sun, Lori Schmid et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1<i>S</i>)-1,2-dihydroxyethyl]-2-pyridyl]-<i>N</i>-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2<i>H</i>-pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management

Laykea Tafesse, Toshiyuki Kanemasa, Noriyuki Kurose et al. · Journal of Medicinal Chemistry · 2014 · 24 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17