Florent Beaufils

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

Arnaud Gautier, Alexandre Juillerat, Christian Heinis et al. · Chemistry & Biology · 2008 · 1.1K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +16

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

Florent Beaufils, Nataša Cmiljanović, Vladimir Cmiljanović et al. · Journal of Medicinal Chemistry · 2017 · 134 citations · Full text

Medicine, Oncology, Pharmacology +14

PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy

Chiara Tarantelli, Eugenio Gaudio, Alberto J. Arribas et al. · Clinical Cancer Research · 2017 · 118 citations

Medicine, Oncology, Pharmacology +13

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Thomas Bohnacker, A.E. Prota, Florent Beaufils et al. · Nature Communications · 2017 · 116 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Total Syntheses of Amphidinolide H and G

Alois Fürstner, Laure C. Bouchez, Jacques‐Alexis Funel et al. · Angewandte Chemie International Edition · 2007 · 115 citations

Natural Sciences, Biochemistry, Chemistry +6