Characteristics of antitumor activity of KW-2189, a novel water-soluble derivative of duocarmycin, against murine and human tumors.

Eiji Kobayashi, Akinao Okamoto, Masao Asada, +6

PubMed

Pharmaceutical ScienceAntitumor ActivityChemoprevention StrategyPathologyPharmacotherapy +15

A Novel Property of Duocarmycin and Its Analogs for Covalent Reaction with DNA

Akira Asai, Satoru Nagamura, Hiromitsu Saito

Journal of the American Chemical Society

Bioorganic ChemistryAltmetric Attention ScoreMolecular BiologyOrganic ChemistryChemical Biology +18

Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole analogues of duocarmycin B2

Satoru Nagamura, Eiji Kobayashi, Katsushige Gomi, +1

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAntitumor ActivityBiochemistryMedicineNatural Sciences +9

Regiospecific sulfonation of secondary hydroxyl groups of .alpha.-cyclodextrin. Its application to preparation of 2A2B, 2A2C-, and 2A2D-disulfonates

Kahee Fujita, Satoru Nagamura, Taiji Imoto, +2

Journal of the American Chemical Society

Medicinal ChemistryChemical MeasurementEngineeringChemical AnalysisBiochemistry +13

Synthesis and Antitumor Activity of Duocarmycin Derivatives: Modification of Segment A of Duocarmycin B2.

Satoru Nagamura, Akira Asai, Yutaka Kanda, +3

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryDuocarmycin DerivativesAntimicrobial ChemotherapySegment APharmaceutical Chemistry +18

Synthesis and Antitumor Activity of Duocarmycin Derivatives.

Satoru Nagamura, Y Kanda, Eiji Kobayashi, +2

Chemical and Pharmaceutical Bulletin

Medicinal ChemistryDerivativesOncologyAntitumor ActivityChemoprevention Strategy +12

Synthesis and antitumor activity of novel duocarmycin derivatives

Akira Asai, Satoru Nagamura, Eiji Kobayashi, +2

Bioorganic & Medicinal Chemistry Letters

Novel Duocarmycin DerivativesMedicinal ChemistryMedicineAnti-cancer AgentPharmacology +3

Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation

Toshiyuki Suzawa, Satoru Nagamura, Hiromitsu Saito, +3

Bioorganic & Medicinal Chemistry

Tumor Specific ActivationMedicinal ChemistryEthylene GlycolBioorganic ChemistryPolymer-drug Conjugate +8

Convenient preparation and effective separation of the C-2 and C-3 tosylates of α-cyclodextrin

Kahee Fujita, Satoru Nagamura, Taiji Imoto

Tetrahedron Letters

EngineeringConvenient PreparationMedicineCyclodextrin ProductionOrganic Chemistry +6

New Water-Soluble Duocarmycin Derivatives: Synthesis and Antitumor Activity of A-Ring Pyrrole Compounds Bearing β-Heteroarylacryloyl Groups

Nobuyoshi Amishiro, Satoru Nagamura, Eiji Kobayashi, +2

Journal of Medicinal Chemistry

Bioorganic ChemistryAntitumor ActivityChemoprevention StrategyOrganic ChemistryPharmacotherapy +18