NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex

Youngmee Kim, Shovanlal Gayen, CongBao Kang, +16

Journal of Biological Chemistry

The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

Anne Benzinger, Grzegorz M. Popowicz, Joma Joy, +3

Cell Research

Non-liganded 14-3-3σ ProteinCrystal StructureBiochemistryBiomolecular Structure PredictionNatural Sciences +3

Strategic Design of Catalytic Lysine‐Targeting Reversible Covalent BCR‐ABL Inhibitors**

David Quach, Guanghui Tang, Jothi Anantharajan, +13

Angewandte Chemie International Edition

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Bee Hui Liu, Chacko Jobichen, C. S. Brian Chia, +18

Proceedings of the National Academy of Sciences

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells

Jothi Anantharajan, Hengbo Zhou, Lingdi Zhang, +20

Molecular Cancer Therapeutics

Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay

Justin Jang Hann Chu, Regina Ching Hua Lee, Melgious Jin Yan Ang, +6

Antiviral Research

MedicineImmunologyAntiviral Drug DevelopmentAntiviral TherapyVirology +5

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia

Haiyan Yang, Lohitha Rao Chennamaneni, Melvyn Wai Tuck Ho, +29

Journal of Medicinal Chemistry

Mixed-phenotype Acute LeukemiaTumor BiologyMyeloid NeoplasiaHematological MalignancyOncology +18

A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir

Subramanyam Vankadara, Monique Danielle Dawson, Jia Yi Fong, +8

ACS Medicinal Chemistry Letters

Protease InhibitorsAntiviral CompoundNirmatrelvir AnalogsCovalent BondMedicine +12

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques

Xiaoying Koh, Joma Joy, Anders Poulsen, +16

Biochemical Journal

Epigenetic ChangeMolecular BiologyChemical BiologyEpigeneticsPrdm Family +19

Identification of covalent active site inhibitors of dengue virus protease

Xiaoying Koh, Joma Joy, Si Fang Wang, +11

Drug Design Development and Therapy