Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity

Nicole K. Paulk, Katja Pekrun, Erhua Zhu, +17

Molecular Therapy

Molecular breeding of viruses

Nay-Wei Soong, Laurel Nomura, Katja Pekrun, +4

Nature Genetics

Viral EvolutionVirologyMolecular BreedingVirus ClassificationVirus Phylogeny

Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors

Katja Pekrun, Gustavo de Alencastro, Qing-Jun Luo, +11

JCI Insight

ImmunologyMolecular BiologyGene DeliveryRegenerative MedicineTranslational Medicine +17

The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner

Adriana Gonzalez‐Sandoval, Katja Pekrun, Shinnosuke Tsuji, +4

Nature Communications

Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors

Fabian P. Suchy, Daiki Karigane, Yusuke Nakauchi, +13

Nature Biotechnology

Molecular VirologyNatural SciencesGeneticsMolecular BiologyVirology +8

Chimeric Human Immunodeficiency Virus Type 1 Containing Murine Leukemia Virus Matrix Assembles in Murine Cells

Margaret A. Reed, Roberto Mariani, Liana Sheppard, +3

Journal of Virology

Chromosome Conformation Paints Reveal the Role of Lamina Association in Genome Organization and Regulation

Teresa Romeo Luperchio, Michael E.G. Sauria, Xianrong Wong, +7

Nuclear StructureGeneticsOverall Chromosome ConformationGenomic MechanismMolecular Biology +19

The repressive genome compartment is established early in the cell cycle before forming the lamina associated domains

TR Luperchio, MEG Sauria, VE Hoskins, +8

GeneticsNuclear LaminaGenomic MechanismCell CycleRepressive Genome Compartment +19

Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model

Song Ren, Katja Pekrun, Themasap A. Khan, +3

Molecular Therapy — Methods & Clinical Development

Attenuated SIV imparts immunity to challenge with pathogenic spleen-derived SIV but cannot prevent repair of the nef deletion

Christiane Stahl‐Hennig, Ulf Dittmer, Thomas Nißlein, +7

Immunology Letters

Nef DeletionSiv Imparts ImmunityPathogenesisImmunologyAntiviral Response +7