Guilherme Meira Lima

Engineered asparaginase from <scp><i>Erwinia chrysanthemi</i></scp> enhances asparagine hydrolase activity and diminishes enzyme immunoreactivity ‐ a new promise to treat acute lymphoblastic leukemia

Iris Munhoz Costa, Débora Custódio Moura, Guilherme Meira Lima et al. · Journal of Chemical Technology & Biotechnology · 2021 · 26 citations · Full text

Engineering, Antimicrobial Chemotherapy, Enzymatic Modification +18

Immature macrophages derived from mouse bone marrow produce large amounts of IL-12p40 after LPS stimulation

Milton Adriano Pelli de Oliveira, Guilherme Meira Lima, Marina Tiemi Shio et al. · Journal of Leukocyte Biology · 2003 · 24 citations

Inflammation, Cytokine, Autoimmune Disease +15

L-Asparaginase from <i>E. chrysanthemi</i> expressed in glycoswitch^®: effect of His-Tag fusion on the extracellular expression

Brian Effer, Guilherme Meira Lima, Sindy Cabarca et al. · Preparative Biochemistry & Biotechnology · 2019 · 22 citations · Full text

Glycosylation of L-asparaginase from E. coli through yeast expression and site-directed mutagenesis

Guilherme Meira Lima, Brian Effer, Henrique Pellin Biasoto et al. · Biochemical Engineering Journal · 2020 · 22 citations · Full text

E. Coli, Biotransformation, Protein Biosynthesis +9

Increased glycosylated l-asparaginase production through selection of Pichia pastoris platform and oxygen-methanol control in fed-batches

Letícia de Almeida Parizotto, Eduardo Krebs Kleingesinds, Luiza Manfrinato Pedrotti da Rosa et al. · Biochemical Engineering Journal · 2021 · 21 citations · Full text

Biosynthesis, Biomanufacturing, Food Fermentation +10