Iris Munhoz Costa

Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity

Iris Munhoz Costa, Leonardo Schultz, Beatriz de Araujo Bianchi Pedra et al. · Scientific Reports · 2016 · 89 citations · Full text

Engineered asparaginase from <scp><i>Erwinia chrysanthemi</i></scp> enhances asparagine hydrolase activity and diminishes enzyme immunoreactivity ‐ a new promise to treat acute lymphoblastic leukemia

Iris Munhoz Costa, Débora Custódio Moura, Guilherme Meira Lima et al. · Journal of Chemical Technology & Biotechnology · 2021 · 26 citations · Full text

Engineering, Antimicrobial Chemotherapy, Enzymatic Modification +18

Glycosylation of Erwinase results in active protein less recognized by antibodies

Brian Effer, Eduardo Krebs Kleingesinds, Guilherme Meira Lima et al. · Biochemical Engineering Journal · 2020 · 20 citations · Full text

Active Protein, Biochemistry, Erwinase Results +9

Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase

Mariane Augusta Domingues Rodrigues, Marcela Valente Pimenta, Iris Munhoz Costa et al. · Biochemical Pharmacology · 2020 · 19 citations · Full text

Medicine, Glycobiology, Immunology +6

Heterologous expression and purification of active L‐asparaginase I of <i>Saccharomyces cerevisiae</i> in <i>Escherichia coli</i> host

João H. P. M. Santos, Iris Munhoz Costa, João Vitor Dutra Molino et al. · Biotechnology Progress · 2016 · 15 citations