Pierre Fraikin - Concepedia

Author

Pierre Fraikin

University of Liège

Also Known As

P. Fraikin, Pierre Fraikin

Publications

350

Citations

H-Index

Concepts

All Affiliations

University of Liège Servier (France)Institut des Hautes Études Scientifiques University of Copenhagen

About

Pierre Fraikin is an author at University of Liège specializing in drug discovery, medicine, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	6	6	226
2	Biochemistry	4	4	122
3	Natural Sciences	3	3	62
4	Social Sciences	2	2	132
5	Biomolecular Engineering	1	1	72

Pierre Fraikin

Publications

284

Citations

H-Index

Page 1

	Year	Citations
Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors Pierre Francotte, Pascal De Tullio, Eric Goffin, Journal of Medicinal Chemistry NeurotransmitterPharmaceutical ChemistrySocial SciencesMolecular PharmacologyMedicinal Chemistry	2007	72
New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Pierre Francotte, Eric Goffin, Pierre Fraikin, Journal of Medicinal Chemistry PharmacotherapyPharmaceutical ChemistrySocial SciencesBenzothiadiazine DioxidesMedicinal Chemistry	2010	60
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators Pierre Francotte, Pascal De Tullio, Tchao Podona, Bioorganic & Medicinal Chemistry MedicineAmpa PotentiatorsOrganic ChemistryChemistrySecond Generation	2008	32
Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure–Activity Relationship at AMPA Receptors A.P. Larsen, Pierre Francotte, Karla Frydenvang, ACS Chemical Neuroscience	2016	30
Chloro-Substituted 3-Alkylamino-4<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity Bernard Pirotte, Pascal De Tullio, Quynh-Anh Nguyen, Journal of Medicinal Chemistry	2009	28
Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2<i>H</i>-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides Pierre Francotte, Ann‒Beth Nørholm, Taru Deva, Journal of Medicinal Chemistry ChemistryChemical BiologyPharmaceutical ChemistryMolecular PharmacologyDiversity Oriented Synthesis	2014	27
Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors Pierre Francotte, Eric Goffin, Pierre Fraikin, Journal of Medicinal Chemistry Thiophenic AnaloguesOrganic ChemistryPharmacotherapyChemistryPharmaceutical Chemistry	2013	21
New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring Eric Goffin, Pierre Fraikin, Dayana Abboud, European Journal of Medicinal Chemistry Molecular PharmacologyDiversity Oriented SynthesisBiochemistryNatural SciencesPositive Allosteric Modulators	2023	14

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