Pierre Fraikin

Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors

Pierre Francotte, Pascal De Tullio, Eric Goffin et al. · Journal of Medicinal Chemistry · 2007 · 72 citations

Neurotransmitter, Pharmaceutical Chemistry, Social Sciences +17

New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors

Pierre Francotte, Eric Goffin, Pierre Fraikin et al. · Journal of Medicinal Chemistry · 2010 · 60 citations

Pharmacotherapy, Pharmaceutical Chemistry, Social Sciences +16

Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators

Pierre Francotte, Pascal De Tullio, Tchao Podona et al. · Bioorganic & Medicinal Chemistry · 2008 · 32 citations

Medicine, Ampa Potentiators, Organic Chemistry +6

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure–Activity Relationship at AMPA Receptors

A.P. Larsen, Pierre Francotte, Karla Frydenvang et al. · ACS Chemical Neuroscience · 2016 · 30 citations

Chloro-Substituted 3-Alkylamino-4<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity

Bernard Pirotte, Pascal De Tullio, Quynh-Anh Nguyen et al. · Journal of Medicinal Chemistry · 2009 · 28 citations · Full text