Frank Jacobs

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Catherine C. Bell, Delilah Hendriks, Sabrina Moro et al. · Scientific Reports · 2016 · 708 citations · Full text

Medicine, Pharmacology, Toxicology +17

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Catherine C. Bell, Anita C. A. Dankers, Volker M. Lauschke et al. · Toxicological Sciences · 2018 · 315 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

E. Wisse, Frank Jacobs, Baki Topal et al. · Gene Therapy · 2008 · 282 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +11

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Ruben Boon, Manoj Kumar, Tine Tricot et al. · Nature Communications · 2020 · 132 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae

Jan Snoeys, Joke Lievens, Eddie Wisse et al. · Gene Therapy · 2007 · 87 citations · Full text

Pharmacy, Genetics, Molecular Biology +16