Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists

Yuefei Shao, Andrew G. Cole, Marc‐Raleigh Brescia, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineReceptor (Biochemistry)Trisubstituted Purinones +3

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders

Qingjie Liu, Qing Shi, David Marcoux, +55

Journal of Medicinal Chemistry

ImmunodeficienciesImmunological DisordersImmunologyImmune RegulationPolar Pyrazole Group +22

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

Lan-Ying Qin, Zheming Ruan, Robert J. Cherney, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistrySelective Pi3kδ InhibitorsMedicineNatural Sciences +6

A multicentre randomized double-blind placebo-controlled phase III study of the efficacy and safety of xeligekimab (GR1501) in patients with moderate-to-severe plaque psoriasis

Lin Cai, Congjun Jiang, Guoqiang Zhang, +37

British Journal of Dermatology

Solid-phase synthesis of N-9-substituted 2,8-diaminopurines

Andrew G. Cole, Axel Metzger, Gulzar Ahmed, +6

Tetrahedron Letters

Synthesis MethodSynthetic ChemistrySolid-phase SynthesisChemistry

Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors

Rajeev S. Bhide, James Neels, Lan-Ying Qin, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySelective Pi3kδ InhibitorsMedicineNatural SciencesRational Drug Design +6

Efficacy and Safety of Crisugabalin (HSK16149) in Adults with Postherpetic Neuralgia

Daying Zhang, Tiechi Lei, Lan-Ying Qin, +48

JAMA Dermatology

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists

Lalgudi S. Harikrishnan, Patrice Gill, Muthoni G. Kamau, +22

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineReceptor (Biochemistry)Pharmacological Agent +3

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists

Andrew G. Cole, Axel Metzger, Marc‐Raleigh Brescia, +21

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineMechanism Of ActionPharmacological Agent +4

A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist

James Kempson, Huiping Zhang, Xiaoping Hou, +21

The Journal of Organic Chemistry

Diversity Oriented SynthesisStereodefined SynthesisMedicineNatural SciencesDiversity-oriented Synthesis +10