Caitlin M. O’Connor

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Jaya Sangodkar, Abbey Perl, Rita Tohmé et al. · Journal of Clinical Investigation · 2017 · 196 citations · Full text

Kras-driven Tumor Growth, Cell Proliferation, Cancer Biology +18

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

Daniel Léonard, Wei Huang, Sudeh Izadmehr et al. · Cell · 2020 · 174 citations · Full text

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

Otto Kauko, Caitlin M. O’Connor, Evgeny Kulesskiy et al. · Science Translational Medicine · 2018 · 152 citations · Full text

Cell Signaling, Medicine, Receptor Tyrosine Kinase +13

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Sarah E. Taylor, Caitlin M. O’Connor, Zhizhi Wang et al. · Cancer Research · 2019 · 58 citations · Full text

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

Caitlin M. O’Connor, Daniel Léonard, Danica Wiredja et al. · Oncogene · 2019 · 46 citations · Full text

Molecular Pharmacology, Mek Inhibitors, Signal Transduction +10