A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

Rogier W. Sanders, Ronald Derking, Albert Cupo, +16

PLoS Pathogens

Bg505 Sosip.664 Gp140Trimeric MimicsHuman RetrovirusImmunologyMultiple Epitopes +13

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

Jean‐Philippe Julien, Albert Cupo, Devin Sok, +9

Science

Virus StructureCrystal StructureTrimer StructureHuman RetrovirusImmunology +11

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Nicole A. Doria‐Rose, Chaim A. Schramm, Jason Gorman, +29

Nature

Developmental PathwayHuman RetrovirusImmunologyAntiviral ResponseVirology +3

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

Dmitry Lyumkis, Jean‐Philippe Julien, Natalia de Val, +9

Science

Viral ReplicationGlycobiologyImmunologyMolecular BiologyViral Structural Protein +14

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Robert Pejchal, Katie J. Doores, Laura M. Walker, +28

Science

ImmunologyGlycobiologyMolecular BiologyImmunodominanceImmunotherapeutics +16

HIV-1 neutralizing antibodies induced by native-like envelope trimers

Rogier W. Sanders, Marit J. van Gils, Ronald Derking, +34

Science

Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers

Claudia Blattner, Jeong Hyun Lee, Kwinten Sliepen, +15

Immunity

Virus StructureViral ReplicationCleavage-dependent EpitopeHuman RetrovirusGp41-gp120 Interface +9

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

Leopold Kong, Jeong Hyun Lee, Katie J. Doores, +24

Nature Structural & Molecular Biology

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

Jean‐Philippe Julien, Devin Sok, Reza Khayat, +19

PLoS Pathogens

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

Pia Dosenovic, Lotta von Boehmer, Amelia Escolano, +21

Cell

Primary ImmunodeficiencyHuman RetrovirusImmunologyAntiviral ResponseAutoimmunity +4